TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection

CARRERA-SILVA EA, CANO RC, PELLEGRINI A, GUIÑAZÚ N, AOKI MP, GEA S.

MOLECULAR IMMUNOLOGY

Año: 2008 vol. 45 p. 3580 - 3580

0161-5890

span style="FONT-SIZE: 12pt; FONT-FAMILY: "Times New Roman"; mso-fareast-font-family: ´Times New Roman´; mso-ansi-language: ES-TRAD; mso-fareast-language: ES-TRAD; mso-bidi-language: AR-SA"> In Chagas disease, which is caused by Trypanosoma cruzi, macrophages andcardiomyocytes are the main targets of infection. Classical activation ofmacrophages during infection is protective, whereas alternative activation ofmacrophages is involved in the survival of host cells and parasites. We studiedthe expression of inducible nitric oxide synthase (iNOS) and arginase as markers of classical and alternative activation, respectively, in heart tissue during in vivo infection of BALB/c and C57BL/6 mice. We found that expression of arginase Iand II, as well as that of ornithine decarboxylase, was much higher i