Inhibitory effects of sulphated flavonoids isolated from Flaveria bidentis on platelet aggregation

GUGLIEMONE HA; AGNESE AM; NUÑEZ MONTOYA S; CABRERA JL

Elsevier

Año: 2005 vol. 115 p. 495 - 495

p style="margin: 0cm -0.05pt 0pt 1cm; text-align: justify;" class="MsoNormal">Inhibitory effects of sulphated flavonoids isolated from Flaveria bidentis on platelet aggregation.  Flaveria bidentis is a plant species that has as major constituents sulphated flavonoids in the highest degree of sulphatation. Among them, quercetin 3,7,3?L,4?L-tetrasulphate (QTS) and quercetin 3-acetyl-7,3?L,4?L-trisulphate (ATS) are the most important constituents. Both showed anticoagulant properties. The objective of the present study was to evaluate the effects of these flavonoids on human platelet aggregation in comparison with the well-known inhibitor quercetin (Qc) by using several agonists. Platelet-rich plasm