Huperzia saururus increases memory retention in rats

VALLEJO, M; ORTEGA, M; CABRERA JL; CARLINI V; RUBIALES DE BARIOGLIO S; AGNESE M

JOURNAL OF ETHNOPHARMACOLOGY

Elsevier

Año: 2007 vol. 111 p. 685 - 685

0378-8741

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; TEXT-ALIGN: justify">Huperzia saururus is reported in Argentinean popular medicine as a memory improver. Chemical studies have shown that the main constituents of the species are Lycopodium alkaloids. On the basis of this information a purified alkaloid extract was obtained by alkaline extraction of the aerial parts. The aim of this work was to investigate the effects of intra – hippocampal administration of the purified alkaloid extract (AE) on memory retention in vivo, using a step down test, in order to correlate with previous results obtained in vitro in an electrophysiological model. The AE administration significantly increased