The alkaloids sauroine and sauroxine facilitate the ejaculation in the fictive ejaculation model

BIRRI M; VALLEJO M; ORTEGA M,; CARRO JUÁREZ M,; AGNESE AM

CABA

Otro; XLIX Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE) ? Reunión conjunta de Sociedades Biomédicas; 2017

SAFE

Phlegmarirurs saururus (Lam.) B. Øllg., an autochthonous species in our country, is used in the ethnomedicineas anaphrodisiac. Previously we demonstrated that the decoction and the alkaloid extracts of this species produce a proejaculatory effect in spinalized male rats. As a result, the objective of the present investigation was to assesswhetherthat effect was produced by its main alkaloids, sauroine and sauroxine. It is known that the ejaculatory response is regulated by the CNS in both the brain and the spinal cord, so if we make a cut at the level of T6 (spinning), we remove the brain control and let the activation of the Spinal Generator of Ejaculation. Thus, sexually experienced male Wistar rats were anesthetized and subjected to surgery to be spinalized. The animals were divided into 6 groups of 3 males each. Control group received saline, reference group was administered with 10 mg/kg of sildenafil, and treatment group received 0.1 and 1 µg/kg of sauroine or sauroxine, all given intravenously. Results showed that both alkaloids facilitate the ejaculation, in view that both produce a diminution in the Latency of Discharge (P<0.05). This means that the motor pattern of ejaculationthat produce the expulsion of the seminal content was activated faster. At the same time, these alkaloids increased the Number of Motor Patterns (P˂0.05), doing that the animals increase their ejaculatory capacity ejaculating a mayor number of times in relation to the controls. Likewise, sauroxine (as it happens with the decoction) produced an increase in the Number of Discharges, promoting an increase in the ejaculatory potency. The effects produced by sauroine and sauroxine were better than those for sildenafil, in all the cases. With these findings, we can affirm that both alkaloids cause a marked aphrodisiac effecton the male spinalized rats explained by the capacity of the alkaloids to promote the ejaculation.