GM1 ganglioside enhances the rewarding properties of cocaine in rats.

VALDOMERO A.; HANSEN C.; GEREZ DE BURGOS N.; CUADRA G.R.; ORSINGHER O.A.

ELSEVIER SCIENCE BV

Año: 2010 vol. 630 p. 79 - 79

span style="FONT-FAMILY: Arial; FONT-SIZE: 11pt; mso-ansi-language: EN-GB; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: ES; mso-bidi-language: AR-SA" lang="en">GM1 pretreatment enhanced the rewarding properties of cocaine as assessed in the conditioned place preference paradigm. This effect was shown by the lower dosage of cocaine necessary to induce conditioning compared with rats receiving cocaine alone, as well as by the fewer number of sessions necessary to induce place preference.GM1pretreatment did not modify the plasma level of cocaine, but it induced a significant increase in the brain cocaine level compared with animals receiving cocaine alone. In order to evaluate the possibility that GM1 pretreatment may alter the pharmacokinetic parameters of cocaine, the brain and plasma esterase activities, the plasma bound/free cocaine ratio and the brain blood barrier permeability to i.v. Evans Blue administration were assessed. None of these parameters w