Resumen:
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In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based
nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and
composition regarding the nanogel size is presented. The thermoresponsive properties of the
synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were
investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell
penetrating properties of the nanogels highlight the potential of such constructs for application as
smart, environmentally-responsive materials.