Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection

MACCHIONE, MICAELA; CARLOS GUERRERO BELTRÁN; ROSSO ANABELLA; EUTI ESTEBAN; MARTINELLI MARISA; STRUMIA MIRIAM; MARIA ÁNGELES MUÑOZ-FERNÁNDEZ

Scientific Reports

Springer Nature Publishing AG

Año: 2019 vol. 9 p. 1 - 1

2045-2322

In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cel