Study of optimización of the synthesis and properties of biocomposite films based on grafted chitosan

ADELAIDA AVILA; KARINA BIERBRAUER; GRACIELA PUCCI; MAR LOPEZ GONZALEZ; MIRIAM STRUMIA

ELSEVIER SCI LTD

Año: 2012 vol. 109 p. 752 - 752

font face="AdvPS497E2" size="1"> In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials. smart, environmentally-responsive materials.