A novel gel based on an ionic complex from a dendronized polymer and ciprofloxacin: Evaluation of its use for controlled topical drug release

MONICA GARCIA; JULIO CUGGINO; CLARISA ROSSET; PAULINA PAEZ; MIRIAM STRUMIA; RUBEN MANZO; CECILIA ALVAREZ I.; ALVARO GIMENEZ KAIRUZ

MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 p. 236 - 236

0928-4931

he development and characterization of a novel, gel-type material based on a dendronized polymer (DP) loadedwith ciprofloxacin (CIP), and the evaluation of its possible use for controlled drug release, are presented in thiswork. DP showed biocompatible and non-toxic behaviors in cultured cells, both ofwhich are considered optimalproperties for the design of a final material for biomedical applications. These results were encouraging for theuse of the polymer loaded with CIP (as a drug model), under gel form, in the development of a new controlled-release system to be evaluated for topical administration. First, DP-CIP ionic complexes were obtainedby an acid-base reaction using the high density of carboxylic acid groups of the DP and the amine groups ofthe CIP. The complexes obtained in the solid state were broadly characterized using FTIR spectroscopy, XRP diffraction,DSC-TG analysis and optical microscopy techniques. Gels based on the DP-CIP complexes were easilyprepared and presente