Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels

MIRIAM STRUMIA

nanomaterials

MDPI

Año: 2022 vol. 12 p. 3835 - 3835

2079-4991

olymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platformsbecause they combine the intrinsic characteristics of both materials with unexpected propertiesthat arise from synergistic effects. In this work, hybrid nanogels based on mesoporous silicananoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties were developed employingultrasound-assisted free radical precipitation/dispersion polymerization. Chemical structure wascharacterized by infrared spectroscopy and nuclear magnetic resonance. Hydrodynamic diameters atdifferent temperatures were determined by dynamic light scattering, and cloud point temperatureswere determined by turbidimetry. Cell viability in fibroblast (NIH 3T3) and human prostate cancer(LNCaP) cell lines were studied by a standard colorimetric assay. The synthetic approach allowscovalent bonding between the organic and inorganic components. The composition of the polymericstructure of hybrid nanogels was optimized to incor