Influence of surface modifications of dendritic polymers in their interaction with albumin

LUCIANA FERNANDEZ; MARISA SANTO; MARISA MARTINELLI; MARCELO CALDERÓN; MIRIAM STRUMIA; NITA CHESSA

Los Cocos. Córdoba

Simposio; III Simposio Argentino-Chileno sobre polímeros; 2005

We have presented a family of dendritic molecules with CN, COOH and butylester superficial groups. They have multiple aromatic head group couple to a lipophilic tail and different termnal groups. These dendrons were utilized in the convergent synthesis of water-soluble dendrons to be evaluated as potential drug carriers.

In view of the use of these macromolecules for durg delivery, it is necessary to know their biological properties such as toxicity and biocompatibility.. Therefore, the interactions between tris-dindrons and human serum albumin were studied.

The dendrons with COOH groups in the surface  presented the best biocompatibility and no-toxicity properties.