Regioselectivity of methyl chlorobenzoate analogues with

MONTAÑEZ J.P.; URANGA, J. G.;; SANTIAGO A. N.

ROYAL SOC CHEMISTRY

Año: 2010 vol. 34 p. 1170 - 1170

p style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">Reactions of methyl 2,5-dichlorobenzoate, methyl 4-chlorobenzoate, methyl 2-chlorobenzoate and methyl 3-chlorobenzoate with Me3Sn- ions gave the corresponding substitution products by an SRN1 mechanism. Competition experiments showed that the relative reactivity of chlorine as the leaving group with respect to the ester group in methyl chlorobenzoate is para >