Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.

MP AOKI, R CANO, A PELLEGRINI, T TANOS, N GUIÑAZÚ, OA COSO, S GEA

MICROBES AND INFECTION

ELSEVIER

Lugar: PARIS-FRANCE; Año: 2006 vol. 8 p. 1723 - 1723

1286-4579

nbsp; Abstract We have recently reported that Trypanosoma cruzi infection protects cardiomyocytes against apoptosis induced by growth factor deprivation. Cruzipain, a major parasite antigen, reproduced this survival effect by a Bcl-2-dependent mechanism. In this study, we have investigated the molecular mechanisms of cruzipain-induced cardiomyocyte protection. Neonatal BALB/c mouse cardiac myocytes were cultured under minimum serum conditions in the presence of cruzipain or T. cruzi (Tulahuen strain). Some cultures were pretreated with the phosphatidylinositol 3-kinase (PI3K) inhibitor Ly294002 or specific inhibitors of the mitogenactivated prot