Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2015 vol. 10 p. 1 - 1

onalcoholic steatohepatitis constitutes a major health concern with the increasing incidence of obesity and diabetes in the world whereas American Trypanosomiasis caused by the protozoan parasite Trypanosoma cruzi is widespread in Latin America but the population migrations have favored its spreading in non-endemic countries. In this work we focus on critical aspects of liver innate and adaptive immunity cells, the TLR4 signaling involvement, inflammatory cytokines and oxidative stress mechanisms underlying in a chronic steatohepatitis physiological model. We also investigate how the T. cruzi infection influences on the evolution of this metabolic disorder. We emphasize that a medium fat diet alone is able to induce steatohepatitis and our data added new evidences demonstrating that this parasitic infection induces marked metabolic changes in the host. Our results suggest a synergic effect between the damage associated to molecular patterns generated during the steatohepatitis pr