Candida albicans up-regulates the Fas-L expression in liver Natural Killer and Natural Killer T cells.

CANO RC

IMMUNOBIOLOGY.

ELSEVIER GMBH

Año: 2015 vol. 220 p. 1210 - 1210

0171-2985

fter Candida albicans arrival to the liver, the local production of proinflammatory cytokines and theexpanded intrahepatic lymphocytes (IHL) can be either beneficial or detrimental to the host. Herein weexplored the balance between protective inflammatory reaction and liver damage, focusing our studyon the contribution of TNF- and Fas?Fas-L pathways in the hepatocellular apoptosis associated to C.albicans infection. A robust tissue reaction and a progressive increase of IL-1, IL-6 and TNF- wereobserved in infected animals. Blocking the biological activity of TNF- did not modify the number ofapoptotic cells observed in C. albicans infected animals. Fas-L molecule was up regulated on purifiedhepatic mononuclear cells and its expression progressed with the infection. In the IHL compartment,the absolute number of Fas-L+ NK and NKT cells increased on days 1 and 3 of the infection. C. albicanswas also able to up regulate Fas-L expression in normal liver NK and NKT cells after in vitro conta