Immune response to a major Trypanosoma cruzi antigen is differentially modulated in C57BL/6 and BALB/c mice

GUIÑAZÚ N, PELLEGRINI A, GIORDANENGO L, AOKI P, RIVAROLA HW, CANO R, RODRÍGUEZ M, GEA S

MICROBES AND INFECTION

ELSEVIER

Lugar: PARIS FRANCIA; Año: 2004 p. 2050 - 2050

1286-4579

nbsp; Abstract BALB/c mice immunized with cruzipain, amajor Trypanosoma cruzi antigen, produce specific and autoreactive immune responses against heart myosin, associated with cardiac functional and structural abnormalities. Preferential activation of the Th2 phenotype and an increase in cell populations expressing CD19+, Mac-1+ and Gr-1+ markers were found in the spleens of these mice. The aim of the present study was to investigate whether cardiac autoimmunity could be induced by cruzipain immuni