High dissemination and hepatotoxicity in ratsHigh dissemination and hepatotoxicity in ratsHigh dissemination and hepatotoxicity in ratsHigh dissemination and hepatotoxicity in ratsHigh dissemination and hepatotoxicity in ratsHigh dissemination and hepatot

SILVIA GRACIELA CORREA1, MARÝA CECILIA RODRÝ´GUEZ-GALA´N1, BEATRIZ SALIDO-RENTERÝ´A1, ROXANA CANO1,

INTERNATIONAL IMMUNOLOGY

Año: 2004 vol. 16 p. 1761 - 1761

0953-8178

nbsp; Abstract The liver constitutes the first barrier in the control of hematogenous dissemination for Candida albicans of intestinal origin. The ability of this organ to limit the growth of the yeast and to mount an efficient inflammatory reaction is crucial in determining the outcome of the fungal infection. When rats infected with C. albicans are exposed to chronic varied stress, the cell recruitment is impaired at the site of the infection, the tissue reaction is highly disorganized in target organs and the infection evolution is more severe. At hepatic level, higher fungal burden is associated with hyphal form and the consistent presence of steatosis (fatty l