TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection

CARRERA-SILVA EUGENIO ANTONIO, CANO ROXANA CAROLINA, GUIÑAZU NATALIA, AOKI MARIA PILAR, PELLEGRINI ANDREA, GEA SUSANA

MOLECULAR IMMUNOLOGY

ELSEVIER

Año: 2008

0161-5890

nbsp; a b s t r a c t Toll-like receptor (TLR) family is crucial for microbial elimination and homeostasis, and has an important immunoregulatory role. In this study, we comparatively analyze innate immune response and tissulartissular injury elicited in BALB/c and C57BL/6 (B6) mice during acute Trypanosoma cruzi infection. The liver was themost affected tissue withnumerous cellular infiltrates, apoptotic cells and necrotic areas. The apoptotic rate, evaluated by Hoescht stain, was highest in liver of B6. Infection increased transaminase activities