Omega-3-Supplemented Fat Diet Drives Immune Metabolic Response in Visceral Adipose Tissue by Modulating Gut Microbiota in a Mouse Model of Obesity

CANO ROXANA CAROLINA

Nutrients

MDPI Suiza

Año: 2023 vol. 15

besity is a chronic, relapsing, and multifactorial disease characterized by excessiveaccumulation of adipose tissue (AT), and is associated with inflammation mainly in white adiposetissue (WAT) and an increase in pro-inflammatory M1 macrophages and other immune cells. Thismilieu favors the secretion of cytokines and adipokines, contributing to AT dysfunction (ATD) andmetabolic dysregulation. Numerous articles link specific changes in the gut microbiota (GM) tothe development of obesity and its associated disorders, highlighting the role of diet, particularlyfatty acid composition, in modulating the taxonomic profile. The aim of this study was to analyzethe effect of a medium-fat-content diet (11%) supplemented with omega-3 fatty acids (D2) on thedevelopment of obesity, and on the composition of the GM compared with a control diet with a lowfat content (4%) (D1) over a 6-month period. The effect of omega-3 supplementation on metabolicparameters and the modulation of the immunological m