Motivational effects of
- and -opioid agonists following acute

NANCY DEL ROSARIO CAPRILES 1, LILIANA MARINA CANCELA

ELSEVIER SCIENCE BV

Año: 2001 vol. 132 p. 159 - 159

font face="TimesNRMT" size="1"> The influence of both acute and chronic restraint stress on the rewarding properties of morphine (1, 2 or 3 mg/kg i.p.) and the aversive effects of naloxone (0.5 mg/kg i.p. ×3 or 1.0 mg/kg i.p.) or bremazocine (0.4 mg/kg i.p.) was investigated. An acute (2 h) but not chronic restraint (2 h daily for 7 days) enhanced the morphine place preference, and elicited a place aversion with a subthreshold dose of bremazocine. This enhancing effect on the reinforcing properties induced by the drugs was prevented by