Artículos
Título:
Chronic Stress Attenuation of a2-Adrenoceptor Reactivity is Reversed by Naltrexone
Autor/es:
L. M. CANCELA, M. VOLOSIN AND V. A. MOLINA
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1988 vol. 31 p. 33 - 33
Resumen:
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CANCELA, L. M., M. VOLOSIN AND V. A. MOLINA. Chronic stress attenuation of a~-adrenoceptor reactivity is
reversed by naltrexone. PHARMACOL BIOCHEM BEHAV 31(1) 33-35, 1988.--Low doses of clonidine (50-100/zg/kg
IP) evoke a clear dose-dependent hypoactivity response. Seven daily immobilization sessions prevented the motor activity
decrease induced by clonidine. On the contrary, a single stress failed to modify clonidine response. Pretreatment with
naitrexone (2 mg/kg IP) fully antagonized the attenuating effect induced by chronic stress on clonidine sedative action.
These evidences suggest that chronic but not acute stress reduces the reactivity of