CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation

LORENZATTI, GUADALUPE; HUANG, WEI; PAL, ANU; CABANILLAS, ANA MARIA; KLEER, CELINA; AMC, CGK (SENIOR AUTHORS)

COMPANY OF BIOLOGISTS LTD

Lugar: Cambridge; Año: 2011 vol. 124 p. 1752 - 1752

font size="2" face="TimesNewRomanPSMT"> NOTA DE LA INVESTIGADORA: DRA KLEER Y DRA CABANILLAS SON CONSIDERADOS ULTIMOS AUTORES, segun consta en la copia del paper. During progression of breast cancer, CCN6 protein exerts tumor inhibitory functions. CCN6 is a secreted protein that modulates the insulin-like growth factor-1 (IGF-1) signaling pathway. Knockdown of CCN6 in benign mammary epithelial cells triggers an epithelial  to mesenchymal transition (EMT), with upregulation of the transcription factor ZEB1/?ÔEF1. How CCN6 regulates ZEB1 expression is unknown. We hypothesized that CCN6 might regulate ZEB1, EMT and breast cancer invasion by modulating IGF-1 signaling. Exogenously added human recombinant CCN6 protein was sufficient to do