CABANILLAS ANA MARIA DE LOS ANGELES
Artículos
Título:
Monoamine oxidase (MAO) and its forms in normal and pathological human thyroid tissues
Autor/es:
ANA MARIA DE LOS A. CABANILLAS; MASINI ANA,; COLEONI ALDO,
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: OXFORD; Año: 1989 vol. 30 p. 681 - 681
Resumen:
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Monoamine oxidase (MAO) activity and its forms were measured in normal human thyroid glands
(39 samples from necropsy and four from perinodular tissues) and in pathological thyroid glands
(13 multinodular goitres, three carcinomas, seven chronic thyroiditis, five Graves´ disease and
seven follicular, seven foetal and five embryonal adenomas). MAO activity in carcinomas was
lower than in normal perinodular thyroid control tissue; in Graves´ disease, foetal and embryonal
adenomas it was significantly higher than in the normal control. The use of clorgyline (a selective
MAO A inhibitor) and deprenyl (selective MAO B inhibitor) allowed estimation of the relative
proportion of MAO forms. A high proportion of MAO A (more than 90%) was observed, both in
normal and in pathological t