Biochemical and functional changes during the bovine fetal thyroid development

ANA MASINI,; ORGNERO GAISAN, ELSA; BONATERRA MONICA,; ANA MARIA DE LOS A. CABANILLAS; COLEONI ALDO,

Mary Ann Liebert

Lugar: CHICAGO; Año: 1998 vol. 8 p. 71 - 71

font size="2" face="Arial"> To establish biochemical and functional relations during thyroid development, the activity of thyroid peroxidase (TPO), nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome c reductase and monoamine oxidase (MAO) in a particulate fraction and the iodide transport and organification in slices of bovine fetal thyroid were examined throughout gestation. The cytochemical localization of TPO, H2O2 generating sites and MAO was also studied. Fetal glands were grouped in stages I to V according to increasing developmental features; adult tissues were also analyzed. TPO activity in each of the fetal stages was higher than in the adult; a marked increase was observed in stages IV and V. Iodide transport (T/M) was similar in stages I to V and the adult. Iodide