Novel DNA photocleavage properties of [Cr(NN)3]3+ complexes

TONEATTO, JUDITH; LORENZATTI, GUADALUPE; CABANILLAS, ANA MARIA; ARGUELLO, GERARDO; AMC, GAA, BOTH SENIOR AUTHORS)

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2012 vol. 15 p. 43 - 43

font size="3" face="Cambria"> NOTA DE LA INVESTIGADORA: DR ARGUELLO Y DRA CABANILLAS SON CONSIDERADOS ULTIMOS AUTORES, segun consta en la copia del paper. Abstract: The aim of this study was to investigate the ability of chromium(III) tris-diimine complexes, [Cr(NN)3]3+, to induce DNA photodamage and to examine its capability to impair the survival of irradiated bacteria with the purpose of using these compounds as photocleavage reagents. [Cr(NN)3]3+ complexes, where NN stands for the ligands: phen (1,10-phenanthroline), 5-Mephen, 4,7- diMephen, 3,4,7,8-tetraMephen, 5-Phphen and 5-Clphen were used for this purpose. Their properties of DNA photocleavage were investigated by electrophoretic studies and assays of the photosensitization of transformed bacteria. The results clearly indicate that [Cr(NN)3]3+ complexes promote the photocleavage of plasmi