Supramolecular analytical chemistry as a convenient alternative

MATÍAS E. CARRANZA; SANTIAGO D. SALAS; MARÍA E. MAJUL ORIHUELA; HUGO M. ELERO; GUADALUPE G. MIÑAMBRES; NATALIA L. PACIONI; ALICIA V. VEGLIA

Carlos Paz, Córdoba

Conferencia; 13th Latin American Conference on Physical Organic Chemistry; 2015

Universidad Nacional de Córdoba

he use of the principles of the supramolecular chemistry with analytical purposes gives place to the supramolecular analytical chemistry. This field involves analytical chemistry applications of synthetic organic and inorganic chemical structures that undergo molecular recognition and self assembly. In the most common embodiment of supramolecular analytical chemistry one creates a sensor.1The research studies in our lab are oriented to the development of new, alternative and enhanced analytical methods based on supramolecular interactions2 for target analytes of biological and environmental implications in human health. Macrocyclic compounds are building blocks in supramolecular systems, acting as receptors of inorganic and organic analytes. These macrocycles have different solubility and polyprotic acid-base properties in aqueous or aqueous/ organic media, depending of their monomeric unit and their subtituents. Among the common receptors we find the family of cyclophanes, and between them the macrocyclic compounds of phenol such as resorcarenes (RA), thiacalixarenes (TCA) and calixarenes (CA). These compounds require their synthesis and a good purification in order to be employed in analytical studies so they have been least studied than cyclodextrins (CD) where the monomeric unit is glucose. The interactions involved between the macrocycle and the target analyte are of different kind and magnitude like van der Walls forces, hydrogen bond and electrostatic interactions. In this report we present the results obtained and the different spectroscopic strategies employed in our lab with the aim to propose supramolecular analytical methods as an alternative for the determination of nitrogen-polycyclic aromatic hydrocarbons (carbazole and quinoline), pesticides (promecarb and paraquat), dietary supplements (cafeic acid) and metallic nanoparticles (AgNP and AuNP). In each case we will discuss the interactions involved (association constant, KA) between the analyte and the macrocyle employed, the analytical performance (detection limit, LD; validation, applicability) of the supramolecular system and we will compare the proposed method with others reported in literature.