Fos is a surface pressure-dependent diverter of phospholipase activity.

GRACIELA ADRIANA BORIOLI; LAURA FANANI,; BEATRIZ CAPUTTO,; BRUNO MAGGIO,

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Año: 2002 vol. 295 p. 964 - 964

0006-291X

c-Fos, a transcription factor, associates to endoplasmic reticulum and modulates phospholipid biosynthesis. Its surface thermodynamic properties allow it to differentially interact with phospholipid monolayers with a selective dependence on the lipid polar head group and the lateral surface pressure. We explored the c-Fos ability to modulate phospholipid degradation by phospholipases (ppPLA2, B.cereus  PLC and sphingomyelinase) using the monolayer technique. Experiments conducted under constant packing conditions show that c-Fos modulates phospholipase activity in a finely tuned way depending on the membrane intermolecular packing. Surface lateral pressures above 12-16 mN/m induce c-Fos to activate phospholipase A2