Adsorption kinetics of c-Fos and c-Jun to air-water interfaces

DEL BOCA M.,; THATYANE, M. N.; GRACIELA ADRIANA BORIOLI; ELISABETE, D. Z. M.; BRUNO MAGGIO,

BIOPHYSICAL CHEMISTRY

ELSEVIER SCIENCE BV

Año: 2007 vol. 130 p. 132 - 132

0301-4622

The surface properties of c-Fos, a regulator of normal and pathologic cell growth and a modulator of phospholipid metabolism, suggest that it has the potential to transduce information through molecular reorganization, placing the nature of its interaction with phospholipids at the basis of its possible effects at a membrane level. Previous studies established that c-Fos induces condensation and depolarization of PIP2 films, and expansion and hyperpolarization of PC. We have now explored more in depth the thermodynamic aspects of these lipid-protein interactions finding that the mixtures have associated hysteresis. The analysis of the excess thermodynamic functions evidences entropic-enthalpic compensations that result i