The surface thermodynamics reveals selective structural information storage capacity of c-Fos-phospholipid interactions

GRACIELA ADRIANA BORIOLI; BRUNO MAGGIO,

LANGMUIR

American Chemistry Society

Año: 2006 vol. 22 p. 1775 - 1775

0743-7463

The surface properties of c-Fos, a regulator of normal and pathologic cell growth and a modulator of phospholipid metabolism, suggest that it has the potential to transduce information through molecular reorganization, placing the nature of its interaction with phospholipids at the basis of its possible effects at a membrane level. Previous studies established that c-Fos induces condensation and depolarization of PIP2 films, and expansion and hyperpolarization of PC. We have now explored more in depth the thermodynamic aspects of these lipid-protein interactions finding that the mixtures have associated hysteresis. The analysis of the excess thermodynamic functions evidences entropic-enthalpic compensations that result in a favo