c-Jun interacts with phospholipids and c-Fos at the interface.

DEL BOCA M.,; CAPUTTO B.L,; MAGGIO B,; GRACIELA ADRIANA BORIOLI

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2005 vol. 287 p. 80 - 80

e describe c-Jun, a widely studied transcription factor that participates in cell proliferation, differentiation, and tumorigenesis, as amphitropic.We show that c-Jun forms stable monolayers and interacts favorably, although in a nonselective manner, with phospholipids at theinterface. The surface activity of c-Jun, together with that of c-Fos, its common partner in AP-1 transcription heterodimers, drives interfacialcomplex formation. We show that AP-1 is very stable at the air–water interface and suggest that AP-1 may not be substantially formed insolution as a stable equimolar association of both proteins.