Artículos
Título:
c-Fos is surface active and interacts differentially with phospholipid monolayers
Autor/es:
GRACIELA ADRIANA BORIOLI; CAPUTTO B.L,; MAGGIO B.,
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Referencias:
Año: 2001 vol. 12 p. 9 - 9
Resumen:
The transcription factor c-Fos
forms stable Gibbs and Langmuir monolayers at the air-buffer interface. Its
marked surface activity is enhanced by penetration into phospholipid films
above the protein's own maximum adsorption surface pressure to a lipid-free
interface. The protein-phospholipid stabilizing interactions at the interface
depend on the lipid polar head group and
the increases of lateral surface pressure generated are comparable to
those of membrane-active proteins. The
surface activity of c-Fos is strong enough to thermodynamically drive and
retain c-Fos at the membrane interface where it may exert direct or indirect
effects.