PEPTIDYLARGININE DEIMINASE TYPE 2 IS OVER EXPRESSED IN THE GLAUCOMATOUS OPTIC NERVE

CRIM N; ROBLES L; CAFARO T; SANTO S; URRETS-ZAVALIA JA,; SERRA HM

MOLECULAR VISION

Año: 2010 p. 1654 - 1654

urpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.