SECONDARY LYMPHOID TISSUE CHEMOKINE (CCL21) IS UPREGULATED IN ALLERGIC CONTACT DERMATITIS.

SERRA, HORACIO MARCELO; EBERHARD, Y; MARTÍN, A. P; GAGLIARDI, J; GALLINO, N; BAENA-CAGNANI, CE; RUIZ LASCANO, A; MARIANI, A. L; UGUCCIONI M,

KARGER

Año: 2004 vol. 133 p. 64 - 64

p style="margin-bottom: 6pt; line-height: 200%;" class="MsoBodyText">Chemokines are important players in the developing of allergic contact dermatitis (ACD). The participation of Secondary lymphoid-tissue chemokine (CCL21) is essential in the induction of the disease due to its expression in lymphatic vessels and in secondary lymphoid organs. Since there is not information about its participation during the effector phase of ACD we studied this chemokine in patients already diagnosed, who were challenged with the relevant (positive) and negative (control) antigens.  All patients showed a specific antigen-induced immune response characterized by early expression of inflammatory markers in blood endothelial cells followe