LYMPHATIC'S PRODUCTION OF CCL21 IN HUMAN IRRITANT CONTACT DERMATITIS

EBERHARD, Y; ORTIZ, S; RUIZ LASCANO, A; KUZNITZKY R,; SERRA, HORACIO MARCELO

BIOMED CENTRAL LTD

Año: 2004 vol. 5 p. 1 - 1

ackground: Expression of murine CCL21 by dermal lymphatic endothelial cells (LEC) has beendemonstrated to be one of the most important steps in Langerhans cell emigration from skin.Previously, our group and others have found that this chemokine is up-regulated in different humaninflammatory skin diseases mediated by diverse specific immune responses. This study was carriedout to investigate the involvement of CCL21 in human skin after challenge with irritant agentsresponsible for inducing Irritant Contact Dermatitis (ICD).Results: Eleven normal individuals were challenged with different chemical or physical irritants.Two patients with Allergic Contact Dermatitis (ACD) were also challenged with the relevantantigen in order to have a positive control for CCL21 expression. Macroscopic as well asmicroscopic responses were evaluated. We observed typical ICD responses with mostlymononuclear cells in perivascular areas, but a predom