THE EFFECT OF KETOTIFEN ON INFLAMMATORY MARKERS IN ALLERGIC CONJUNCTIVITIS

MARTÍN A,; URRETS-ZAVALIA J,; BERRA A,; MARIANI, AL; GALLINO N,; DEMEL E, GOMEZ; GAGLIARDI J,; BAENA-CAGNANI CE,; URRETS-ZAVALIA E,; SERRA, HORACIO MARCELO

Bmc Ophtalmology

BMC

Año: 2003 vol. 3 p. 2 - 2

1471-2415

ackground: The efficacy and safety of ketotifen eye drop treatment in allergic conjunctivitis (AC)management is perfectly known by several studies, but the mechanism of action at the biochemicallevels is poorly understood so we decided to perform an open, uncontrolled study in order toinvestigate the effect of the topical administration of ketotifen fumarate 0.05% on biochemicalmarkers of inflammation on conjunctival cells in patients with AC.Methods: Nineteen patients with symptoms and signs of AC (itching, discharge, burning, redness,increase in the watery discharge, swelling and follicles) and with a history of allergy were prescribedwith two daily instillation of one drop of eyewash ketotifen fumarate 0,05% in both eyes duringthirty days. They were studied by measuring clinical and immunologic parameters.Results: Ketotifen fumarate treatment significantly reduced the total symptoms and signs scorefor each patient as well