DEVELOPMENT OF HIGH POTENCY UNIVERSAL DR RESTRICTED HELPER EPITOPES BY MODIFICATION OF HIGH AFFINITY DR BLOCKING PEPTIDES

ALEXANDER, J; SIDNEY, J; SOUTHWOOD, S; RUPPERT, J; OSEROFF, C; SNOKE, K; SERRA, HORACIO MARCELO; KUBO,R; SETTE, A; GRAY, H

CELL PRESS

Año: 1994 vol. 1 p. 1 - 1

!--[if gte mso 9]> Normal 0 21 false false false Pan DR-binding peptides engineered by introducing anchor residues for different DR motifs within a polyalanine backbone bound 10 of 10 DR molecules tested, with affinities, in most cases, in the nanomolar range. Because o