n subjects
receiving the radiolabeled allergen orally, plasma radioactivity rapidly
increased, peaking at about 30 minutes.
In subjects
given 123I-Par j 1 sublingually, plasma radioactivity was not detectable until
swallowing.
After
swallowing, plasma radioactivity rose and strictly paralleled that of the oral
route.
In subjects
given the radiolabeled allergen intranasally, plasma radioactivity
progressively increased, consistent with esophageal transit and absorption
through the
gastroenteric
tract of the amount of allergen transported from the nose to the pharynx.
The pattern of
plasma radioactivity disappearance after peak was similar in all groups.
Chromatographic
analysis showed that the pattern of total radioactivity in plasma does not
accurately reflect the fate of the allergen.
Gel filtration
of plasma through Sephadex G-25 columns invariably showed a major peak in the
low molecular weight region (free iodine
and small peptides),
No degradation
of the radiolabeled allergen was observed to occur in the sublingual space up
to 20 minutes.
