Purpose. To evaluateassociation of glaucoma and presence of dilated episcleral vessels with Sturge-Weber syndrome.

Methods. After asystematic literature search (PubMed, EMBASE, and Cochrane Library), allrelevant studies evaluating the association between Sturge-Weber Syndrome (SWS),Glaucoma and dilated episcleral vessels were included. All statistical testswere calculated with Stata 11.0. Mass spectrometric analyses of glaucomatousoptic nerve tissues (n=11) and controls (n=15) including SWS associatedglaucoma (n= 2).

Results. From 1950to this date, 241 independent studies of ocular defects in SWS and associationof glaucoma with or without the record of presence of dilated episcleralvessels have been recorded. SWS  isalmost always associated with Glaucoma. However, subgroup analyses showsstatistically significant association with dilated episcleral vessels or otheranterior chamber vessel abnormalities as well. Proteomic analysis of trabecularmeshwork tissue showed presence of a protein: Statherin in the optic nervetissue of glaucomatous donors but not in controls.

Conclusion. Glaucomaand dilated episcleral vessels have a high association prevalence with SWS.Statherin, a protein found in glaucomatous optic nerve has also been found inSWS patients? optic nerve.