B cell response during protozoan parasite infections

AMEZCUA VESELY, MARIA CAROLINA; BERMEJO, DANIELA A; MONTES, CAROLINA LUCIA; ACOSTA RODRIGUEZ E V; GRUPPI, ADRIANA

Journal of Parasitology Research

Hindawi Publishing corporation

Año: 2012 p. 362131 - 362131

2090-0023

n this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultane