The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.

GOROSITO SERRAN, MELISA; FIOCCA VERNENGO, FACUNDO; BECCARIA, CRISTIAN G; ACOSTA RODRIGUEZ, EVA VIRGINIA; MONTES, CAROLINA LUCIA; GRUPPI, ADRIANA

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015

he term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer.