Dietary supplementation with probiotics improves hematopoiesis in malnourished mice.

SALVA, SUSANA; MERINO, MARIA CECILIA; AGUERO, GRACIELA; GRUPPI, ADRIANA; ALVAREZ, SUSANA

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2012 p. 31171 - 31171

actobacillus rhamnosus CRL1505 (Lr) administered during the repletion of immunocompromised-malnourished mice improves the resistance against intestinal and respiratory infections. This effect is associated with an increase in the number and functionality of immune cells, indicating that Lr could have some influence on myeloid and lymphoid cell production and maturation.OBJECTIVE: This study analyzed the extent of the damage caused by malnutrition on myeloid and lymphoid cell development in the spleen and bone marrow (BM). We also evaluated the impact of immunobiotics on the recovery of hematopoiesis affected in malnourished mice.METHODS:Protein malnourished mice were fed on a balanced conventional diet for 7 or 14 consecutive d with or without supplemental Lr or fermented goat´s milk (FGM). Malnourished mice and well-nourished mice were used as controls. Histological and flow cytometry studies were carried out in BM and spleen to study myeloid and lymphoi