Peritoneum from Trypanosoma cruzi infected mice is a homing site of Syndecan-1neg plasma cells which provide non-parasite specific antibodies

MERINO, MARÍA CECILIA; MONTES, CAROLINA LUCIA; ACOSTA RODRIGUEZ EVA; BERMEJO, DANIELA A; AMEZCUA VESELY, MARIA CAROLINA; GRUPPI, ADRIANA

OXFORD UNIV PRESS

Año: 2010 vol. 22 p. 399 - 399

font size="1" face="AdvPSHEL-B"> Humoral immunity during experimental Chagas disease has been considered a double-edge sword,critical to control Trypanosoma cruzi spreading but also associated to tissue damage. Peritoneal B-1cells have been linked to the pathogenesis of Chagas disease; however, they may also help to controlthe infection by providing a fast wave of antibodies. In the present work, we determined thatperitoneal B-cell response to T. cruzi is characterized by a marked reduction of CD191 B cells due toplasma cell differentiation rather than to cell death. Both peritoneal B-2 and B-1 cells decrease afterparasite infection, but with different kinetics. Thus, the reduction in B-2 cell number can be detectedfrom day 4 postinfection while the number of B-1 cells decreases only after 15 days of infection.Differentiation of peritoneal B-1 and B-2 cells into IgM-secreting cell