Effects of quercetin and menadione on intestinal calcium absorption and the underlying mechanisms

A. M. MARCHIONATTI; A. DEL V. PACCIARONI,; NORI G. TOLOSA DE TALAMONI

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2013 vol. 164A p. 215 - 215

uercetin (QT) could be considered as a potential therapeutic agent for different diseases due to its antioxidant,anti-inflammatory, antiviral and anticancer properties. This study was designed to investigate the abilityof QT to protect the chick intestine against menadione (MEN) induced injury in vivo and in vitro.Four-week old chicks (Gallus gallus) were treated i.p. with 2.5 μmol of MEN/kg b.w. or with i.l. 50 μM QTor both. QT protected the intestinal Ca2+ absorption against the inhibition caused by MEN, but QT alonedid not modify. Glutathione (GSH) depletion provoked by MEN in chick enterocytes was abolished by QTtreatment, whereas QT alone did not modify the intestinal GSH content. The enhancement of GSH peroxidaseactivity produced by MEN was blocked by QT treatment. In contrast, superoxide dismutase activity remainedhigh after simultaneous treatment of enterocytes with MEN and QT. The flavonol also avoided changes in the