Antioxidant and free radical scavening activities in Misodendrum punctulatum, myzodendrone and structurally related phenols.

CRISTIAN DESMARCHELIER; ADRIANA DEL V. PACCIARONI; GLORIA L. SILVA; GRACIELA CICCIA; ROBERTO R. GIL

PHYTOTHERAPY RESEARCH

John Wiley

Lugar: Londres; Año: 2005 vol. 19 p. 1043 - 1043

0951-418X

p>Peroxyl radical scavenging activity of a methanol extract of Misodendrum punctulatum was determined by means of luminol-enhanced chemiluminescence assay, allowing to calculate the total reactive antioxidant potential (TRAP) index equal to 239 ± 26 m M, expressed in trolox equivalents. The flavan-3-ol catechin (1) and the phenylbutanone derivative myzodendrone (2) were identified through bioassay guided fractionation as the active principles present in the extract, and their structures were elucidated by chemical and spectroscopic analysis. Three structurally related synthetic phenols, dehydrozingerone (3), zingerone (4), and myzodendrone aglycone (5), were also analyzed using this method. Compounds 1 and 2 were highly effective as free radical scavengers (TRAP = 1257 m M and 1018 m M, respectively), when compared to trolo