Conversion of (-)-Ambroxide by whole cells of Fusarium verticillioides

DANIELA BUSTOS CRESCENTINO; ADRIANA PACCIARONI; DANIEL BUSTOS; VIRGINIA E. SOSA.

AMER SOC MICROBIOLOGY

Lugar: Washington; Año: 2015

n recent years, biotransformations have received increasing interest and has become one of the most promising areas of scientific research, because is a very useful tool for organic chemists to functionalize organic compounds and due to its potential application in the production of useful products in different industrial processes. This methodology is highly relevant since it can be an easy way to introduce a functional group in a non-reactive carbon, regio- and stereoselectively, in mild conditions and avoiding polluting the environment. The use of whole cells of pathogenic fungi as a source of enzymes, is very interesting because of the large number of genera and species that form and the variety of enzymatic processes that can be achieved by them. In this paper it was performed the microbial transformation of (-)-ambroxido (1), using enzymes present in whole cells of the phytopathogenic fungus Fusarium verticillioides. Furthermore, the bioactivity of the starting compound and the