Synthesis and Physicochemical Properties of Polyacrylamide Nanoparticles as Photosensitizers Carriers

GUALDESI, MARÍA S; ALVAREZ IGARZABAL, CECILIA; VARA, JIMENA Y ORTIZ*, CRISTINA

INTERNATIONAL JOURNAL OF PHARMACEUTICS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016

0378-5173

t present, polyacrylamide nanoparticles are attractive to drug delivery. However, some physicochemicalcharacteristics of these nanoparticles still need to be further improved in practice. Polyacrylamidenanoparticles with an average size of 80 nm and a zeta potential of30 mV were synthesized and used asphotosensitizer carriers. The new monobrominated derivatives and parent compounds were thephotosensitizers for the photodynamic therapy loaded in the nanocarrier.The physicochemical characterization of the prepared nanoparticles, drug loading, the ability togenerate singlet oxygen and chemical stability were investigated.The novel tested nanoparticles exhibited a loading percentage of between 80 and 99%, highergeneration of singlet oxygen and good stability in comparison with the corresponding starting reagent.According to these results, the novel polyacrylamide nanoparticles are excellent candidates for drugvehiculization.