Neutral red monobrominated as photoantimicrobial agent against Staphylococcus aureus.

URRUTIA M, ALOVERO F, ORTIZ C

International Journal of Pharmaceutical Sciences and Research

International Journal of Pharmaceutical Sciences and Research

Año: 2015 p. 58 - 58

2320-5148

eutral red monobrominated as photoantimicrobial agent against Staphylococcus 1 aureus 2 3 Keywords: Neutral Red, Photosensitizer, Photodynamic Antimicrobial Chemotherapy 4 5 Photodynamic Antimicrobial Chemotherapy was proposed as an alternative treatment 6 for localized infections in response to the worldwide problem of resistance because of 7 its efficacy and to be less likely to induce resistance. Neutral Red monobrominated 8 (NRBr) is a new azine compound synthesized in our laboratory derivated from Neutral 9 Red (NR). In a previous work, NRBr showed physicochemical and photophysical 10 properties appropriate for potencial use as a photosensitizer (PS). In this study, the 11 photoantimicrobial effect was evaluated in S.aureus. Simultaneously, NR was assayed 12 since reports on effects against bacteria are limited. 13 S.aureus ATCC 25923 and methicillin- and fluoroquinolone-resistant S.aureus isolate 14 (MRSA61) were used to determine effect of PS concentration (5-200 μM) an