Physicochemical properties and photodynamic activity of novel derivatives of Triarlylmethane and Thiazine

MONTES DE OCA, M N, VARA J, MILLA L, RIVAROLA V, ORTIZ, C

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2013 vol. 346 p. 255 - 255

riarylmethane and thiazine dyes have attracted attention as anticancer and antimicrobial agents, due to their structural features and selective localizations. Although these dyes have been initially explored in the context of photodynamic therapy, some of these such as New Fuchsin and Azure B have still not been extensively investigated. For this reason, we evaluated the chemical stability, aggregation effect, and lipophilicity, as well as the photodynamic activity against LM-2 murine mammary carcinoma cells of five new brominated dyes of triarylmethane and thiazine. These cationic compounds were obtained at high purities and unequivocally characterized by conventional techniques. The introduction of bromine atoms into the chromophoric system of New Fuchsin and Azure B dyes gave rise to a moderate bathochromic shift and increased the lipophilicity, thereby improving their photophysical and photochemical properties for biomedical applications.Moreover, the in vitro photodynami