Electrochemical study of flunitrazepam partitioning into zwitterionic phospholipid monolayers

L.M.A. MONZÓN; L.M. YUDI

ELECTROCHIMICA ACTA

Elsevier

Lugar: Lausanne, Suiza; Año: 2006 vol. 51 p. 1932 - 1932

0013-4686

font face="Times New Roman" size="1"> The effect of flunitrazepam (FNTZ) on molecular packing of distearoylphosphatidylcholine (DSPC) and distearoylphosphatidylethanolamine(DSPE) monolayers adsorbed at the water/1,2-dichloroethane interface was investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).The interfacial packing of the monolayer was estimated by the analysis of the voltammetric transfer of tetraethylammonium cation (TEA+) from the aqueous to the organic phase in the presence of different cations (Li+, Ca2+ and K+) in water. An important blocking of the transfer process was ob