Flunitrazepam effect on distearoylphosphatidylglycerol, cholesterol and distearoylphosphatidylglycerol + cholesterol mixed monolayers structure at a DCE/water interface

L.M.A. MONZÓN; L.M. YUDI

ELECTROCHIMICA ACTA

Elsevier

Lugar: Lausanne - Suiza; Año: 2006 vol. 51 p. 4573 - 4573

0013-4686

font face="Times-Roman" size="1"> The effect of Flunitrazepam (FNTZ) on molecular packing of distearoylphosphatidylglycerol (DSPG), cholesterol (CHOL) monolayers and DSPG +CHOL mixed monolayers adsorbed at the water/1,2-dichloroethane interface was investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The interfacial packing of the monolayer was estimated by the analysis of the voltammetric transfer of tetraethylammonium cation (TEA+) from the aqueous to the organic phase in the presence of different cations (Li+, Ca2+ and K+) in water. An important blocking of the transfer process was observed in the case of DSPG